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Subject: harnessing nanowork

Date: 11/07/00 at 7:24 AM
Posted by: Maggie Pitman
E-mail: pitwoman@hvc.rr.com
Message Posted:

To the micromaching engineers out there, what physical scale do you
think is best to merge micromachined parts with supramolecular/ self
assembled machinery?
When designing systems from the bottom up, the larger they are, the
more difficult they are to characterize in atomic detail. For
micromachined parts, I imagine the smaller they are, the more difficult
assembly and manipulation is.
So say I could design, via protein engineering, a complex of
proteins that perform a certain task such as catalyzing an exothermic
reaction which drives a series of conformational changes. Lets say each
of these proteins are about 5 nanometers across and roughly cubic.
Several of these systems converge on another component which allows the
work to be additive in some sense.. Lets put four of the smaller
together on a 2D matrix and let them converge on one 10X10 nanometer

If this was repated by building larger and larger protein complexes,
at what scale would it be feasible to fabricate micromachined components
that touch down and harness work?

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